The Prince Edward Island Marine Protected Area is an offshore conservation region near the Prince Edward Islands in the exclusive economic zone of South Africa, nearly 2,000 km southeast of South Africa in the Indian Ocean.

[1] The Prince Edward Islands have been managed as a special nature reserve since November 1995, but there was originally no marine component.

The Minister of Environmental Affairs and Tourism (DEAT), Martinus van Schalkwyk, announced South Africa's intention to declare a large MPA around the sub-Antarctic Prince Edward Islands in June 2004.

[5] The Prince Edward Islands MPA is intended to stop the decline of the Patagonian toothfish, which has been critically over-exploited, and to reduce the seabird bycatch of the fishery, particularly of albatrosses and petrels.

[5] The Department of Agriculture, Forestry and Fisheries is responsible for issuing permits, quotas and law enforcement.