[2] War with France had just begun and Captain Henry Hanwell acquired a letter of marque on 8 April 1793.

In 1811 Prince of Wales, Eddystone, and Edward and Ann carried immigrants to Hudson Bay.

On 1 June 1813 three merchant vessels sailed from Gravesend, bound for Hudson Bay: Prince of Wales, Eddystone, Ramsay, master, carried employees of the Hudson's Bay Company, and Ann, Neale, master, was taking a party of Moravian missionaries.

On the way fever broke out on Prince of Wales, which resulted in the death of a number of the emigrants.

[1] On 16 July 1821, Prince of Wales, Eddystone, and Lord Wellington were sailing in company to York Factory in Hudson Bay when they encountered HMS Fury and Hecla at 61°20′N 66°30′W / 61.333°N 66.500°W / 61.333; -66.500.

[5] On 24 June 1826 as Prince of Wales was sailing out of Hoy Sound, bound for Hudson Bay, she struck a rock and was stuck there for four hours.

Prince of Wales, Captain Dannet, master, was the last to see Sir John Franklin's expedition to the Arctic.

On 26 July 1845 she was at 74°48′N 66°13′W / 74.800°N 66.217°W / 74.800; -66.217 in Lancaster Sound, Baffin Bay and there saw HMS Erebus and Terror moored to an iceberg.