Her godparents are her uncle Prince Constantijn, Crown Princess Victoria of Sweden, the (then) vice-president of the Council of State of the Netherlands Herman Tjeenk Willink, her mother's friend Samantha Deane, her uncle Martín Zorreguieta, and her father's friend Marc ter Haar.

[7] Her birthdays are traditionally celebrated with a concert at the Kloosterkerk in The Hague, which is attended by ambassadors and members of the royal household and the Council of State of the Netherlands.

[13][2] As of 5 September 2022 Catharina-Amalia is studying at the University of Amsterdam for a Bachelor of Science[14] degree in Politics, Psychology, Law and Economics (PPLE).

[15] During her second month in university, she was moved back to the royal palace from her student housing in Amsterdam due to security risks.

[16] In April 2024, King Willem-Alexander revealed that Catharina-Amalia lived in Madrid in 2023 under the protection of the Spanish monarchy, while she continued her studies online, due to the threats from the Moroccan mafia, a criminal organization dedicated to drug trafficking that has been threatening to kidnap her.

[24] On 8 December 2021, Catharina-Amalia assumed her seat in the Advisory Division of the Council of State when she reached the age of majority at 18 the day before.

[28][29] An outdoor birthday party thrown by her family to mark the occasion was found to be in breach of regulations and restrictions imposed during the COVID-19 pandemic, which made her father admit that "it was not right to organize this".

[39] On 5 May 2023, she accompanied her grandmother to a reception held at Buckingham Palace the evening before the coronation of King Charles III and Queen Camilla of the United Kingdom.

[40] In June 2023, she and her parents attended a state banquet honoring the wedding of Crown Prince Hussein of Jordan and Rajwa Al Saif.

[42] Catharina-Amalia attended her first state banquet, honouring King Felipe VI and Queen Letizia of Spain, in April 2024.

[43] Catharina-Amalia has experienced repeated fat shaming by tabloids and on social media since she was young, most notably by the Portuguese celebrity magazine Caras labeling her as plus size.

[47] In May 2024, citing changed circumstances, Catharina-Amalia announced she would begin utilizing her annual allowance for staff and operational expenses, starting in January 2025.