She was the eldest daughter of the future Victor Amadeus I, Duke of Savoy and his wife Christine Marie of France.

[1] However, being a female and due to the Salic law, she was barred from succeeding to the Duchy of Savoy which at the time of her birth was ruled by her grandfather Charles Emmanuel I. Luisa Cristina was said to have been illegitimate and the fruit of her mother's supposed affair with a French courtier named "Pommeuse".

Her mother, Christine Marie, took over as regent, a development which was disputed by Luisa Cristina's uncles Thomas Francis, Prince of Carignano and Cardinal Maurice.

Luisa Cristina's mother was soon victorious in the ensuing wars thanks to French support in the form of her brother, Louis XIII.

[4] Luisa Cristina died at the villa and left the property to her nephew's consort, the French born Anne Marie d'Orléans.