In 1865, Marguerite became romantically involved with her first cousin, Louis of Orléans, Prince of Condé, but the young man's premature death the following year put an end to their plans.

For some years she had been suffering from tuberculosis and had ceased to play a part in the society of the Faubourg, of which she was once so bright an ornament; henceforth, she devoted all her remaining strength to the care of her two children, Princes Adam and Withold.

One night she was brought from the sanatorium near Frankfurt, where the summer was spent, to the Hôtel Lambert, her Paris home, "in a well-nigh hopeless state."

She rallied, however, and on Tuesday, at the usual dinner-hour, she was able to take some nourishment, looking forward to congratulating her father, Prince Louis, Duke of Nemours, the next day on the eightieth anniversary of his birth.

[6] She was buried in Saint-Louis-en-l'Île, Paris, but after some time, both her grave and that of her husband Władysław, were moved to the Czartoryski family crypt in Sieniawa, Poland.