Maria Amalia of Saxony (26 September 1757 – 20 April 1831) was a Duchess consort of Zweibrücken by her 1774 marriage to Charles II August, Duke of Zweibrücken.

In Dresden 1774, Maria Amalia married Charles of Zweibrücken-Birkenfeld.

His sister had already been married to Maria Amalia's brother Frederick since 1769.

Maria Amalia and her husband had only one son, who died in childhood.

Maria Amalia died on 20 April 1831 in Neuburg, outliving her husband by 36 years.