Princess Maria Anna of Hesse-Homburg (13 October 1785, Bad Homburg vor der Höhe – 14 April 1846, Berlin) was a German noblewoman.

Maria Anna belonged to the anti-Napoleon-party around Queen Luise and supported the war against France in 1806.

In March 1813, she proclaimed the famous "Aufruf der königlichen Prinzessinnen an die Frauen im preußischen Staate" and founded the patriotic women's association "Vaterländischen Frauenverein."

She corresponded with Freiherr vom Stein, von Hardenberg and the Humboldt brothers and was an acquaintance of the poet Friedrich de la Motte Fouqué.

She married in 1804 to Prince Wilhelm of Prussia (1783–1851), her first cousin, and they had nine children: This article about a member of the German nobility is a stub.