Princess Maria Eleonore of Hesse-Rotenburg (Maria Eleonore Amalia; 25 February 1675 – 27 January 1720) was Landgravine of Hesse-Rotenburg by birth and was the Countess Palatine of Sulzbach by marriage.

Maria Eleonore was the second child of William, Landgrave of Hesse-Rotenburg and his wife Countess Maria Anna of Löwenstein-Wertheim-Rochefort.

She was an older sister of Ernest Leopold of Hesse-Rotenburg, future ruler of her native Hesse-Rotenburg.

Engaged to Theodore Eustace of Sulzbach, the heir of the ruling Count Palatine of Sulzbach Christian Augustus, the couple were married on 9 June 1692 in Lobositz, Bohemia.

She died in Sulzbach at the age of 44.