Born at the Landgrave's Palace in Rotenburg an der Fulda to Constantine, Hereditary Prince of Hesse-Rotenburg and his wife, Countess Sophia Theresia Hedwigis Eva of Starhemberg (1722-1773), widow of William Hyacinth, Prince of Nassau-Siegen and sister of Georg Adam, Prince of Starhemberg.
On 17 July 1766 at Carlsburg she married Jacques Léopold de La Tour d'Auvergne, Prince de Turenne and heir to the sovereign Duchy of Bouillon.
Her husband lived in Navarre prior to the revolution and succeeded his father in 1792.
During the collapse of the ancien régime, the duchy of Bouillon was taken from him in 1794 and absorbed into France in October 1795.
However, in 1800, he recovered the duchy but was obliged to pay off debts of 3 million livres.