Princess Sophie Charlotte of Brandenburg-Bayreuth (Sophie Charlotte Albertine; 27 July 1713 – 2 March 1747), was a German noblewoman member of the House of Hohenzollern and by marriage Duchess of Saxe-Weimar and Saxe-Eisenach.

Born in Weferlingen, she was the fourth of five children born from the marriage of George Frederick Charles, Margrave of Brandenburg-Bayreuth and Princess Dorothea of Schleswig-Holstein-Sonderburg-Beck.

[1][better source needed] In 1716 her mother was convicted of adultery and imprisoned; she probably never saw her again.

In Bayreuth on 7 April 1734, Sophie Charlotte married Ernest Augustus I, Duke of Saxe-Weimar as his second wife.

They had four children: On 26 July 1741 she also became the Duchess consort of Saxe-Eisenach after her husband inherited that land.