First published in 1981 by McGraw-Hill, Principles of Neural Science is an influential neuroscience textbook edited by Columbia University professors Eric R. Kandel, James H. Schwartz, and Thomas M. Jessell.

Several authors are also highly decorated scientists, including Nobel laureate Linda B. Buck and renowned neurophysiologist Roger M. Enoka.

Principles of Neural Science is often assigned as a textbook for many undergraduate and graduate/medical neuroscience and neurobiology courses.

The book attempts to at least introduce every aspect of our most modern understanding of the brain.

The sixth edition is divided into sixty-four chapters, organized into nine parts: