Priolo Gargallo (Sicilian: Priolu) is a comune (municipality) in the Province of Syracuse, Sicily (southern Italy).

Priolo Gargallo borders the following municipalities: Melilli, Syracuse, Solarino, Sortino.

Priolo Gargallo is the location of the Priolo Gargallo complex, which encompasses the two refineries ISAB NORD and ISAB SUD owned by the Russian conglomerate Lukoil.

These refineries are interconnected via a network of pipelines and collectively possess a total processing capacity of 16 million metric tons per year.

[3] With substantial production capabilities and prime geographic positioning, the Priolo Gargallo complex plays a crucial role in ensuring energy stability and supply in the region, contributing to both local and international energy markets.