Priscilla, Queen of the Desert is a jukebox musical with book by Australian film director-writer Stephan Elliott and Allan Scott, using well-known pop songs as its score.

As they head west from Sydney aboard their lavender bus, Priscilla, the three friends come to the forefront of a comedy of errors, encountering a number of strange characters, as well as incidents of homophobia, while widening comfort zones and finding new horizons.

The drag queen Mitzi Mitosis – stage name of Anthony "Tick" Belrose – is performing at a club ("Downtown" [Australia and London]/"I've Never Been to Me"; "It's Raining Men" [Broadway]) when his estranged wife Marion, calls in for a favour.

Tick also asks a friend Felicia – stage name of Adam Whitely – to come with them ("Venus"/"Material Girl"), with Bernadette taking an immediate dislike to his show-off performance style.

Later when they arrive, Adam dresses up like a woman to try to meet men ("Hot Stuff"), but ends up getting chased and nearly becomes the victim of a hate crime until Bernadette rescues him by kicking one of his attackers.

Priscilla, Queen of the Desert premiered on 7 October 2006 at the Lyric Theatre, Star City Casino, Sydney, Australia and ended its run on 2 September 2007.

In Brazil Priscilla ran at the Teatro Bradesco, São Paulo, from 16 March to 9 December 2012, produced by GEO Eventos, BASE Entertainment and Nullarbor Productions, and starring Luciano Andrey as Tick/Mitzi, Rubén Gabira as Bernadette, André Torquato as Adam/Felicia, Li Martins as Cynthia and Saulo Vasconcelos as Bob.

[14] After the show closed on Broadway, a national tour opened on 8 January 2013 at the Orpheum Theatre in Minneapolis, Minnesota with Wade McCollum as Tick/Mitzi, Scott Willis as Bernadette, and Bryan West as Adam/Felicia.

A Swedish production ran from 21 September 2013 to 18 May 2014 at the Göta Lejon in Stockholm, with Patrik Martinsson as Tick/Mitzi, Björn Kjellman as Bernadette, Erik Høiby as Adam/Felicia, and Pernilla Wahlgren as one of the Divas.

[19] A non-replica staging premiered on 5 February 2014 at the Teatro Lola Membrives, Buenos Aires, starring Alejandro Paker as Tick/Mitzi, Pepe Cibrián Campoy as Bernadette, and Juan Gil Navarro as Adam/Felicia.

[20] The Buenos Aires production closed on 31 August 2014 and then was transferred to Teatro Candilejas in Villa Carlos Paz, with Alejandro Paker reprising as Tick/Mitzi, Moria Casán as Bernadette, and Diego Ramos as Adam/Felicia.

[21] In Greece the show opened on 6 May 2014 at the Badminton Theater in Athens, where it ran until 15 June 2014, with Giorgos Kapoutzidis as Tick/Mitzi, Fotis Sergoulopoulos as Bernadette, and Panagiotis Petrakis as Adam/Felicia.

A non-replica production ran from 9 May to 13 July 2014 at the Newport Performing Arts Theater in Resorts World Manila, with Leo Tavarro Valdez as Tick/Mitzi, Jon Santos as Bernadette, and Red Concepción as Adam/Felicia.

[22] After a limited engagement from 16 to 26 October 2014 at the Resorts World Theatre in Sentosa, Singapore,[23] the production came back to the Newport Performing Arts Theater in Manila from 28 November to 7 December 2014.

[24] In Spain Priscilla premiered on 2 October 2014 at the Nuevo Teatro Alcalá, Madrid, with Jaime Zataraín as Tick/Mitzi, Mariano Peña and José Luis Mosquera alternating as Bernadette, Christian Escuredo as Adam/Felicia, David Venancio Muro as Bob, Rossana Carraro, Patricia del Olmo and Aminata Sow as The Divas, Susan Martín as Marion, Cristina Rueda as Shirley, Etheria Chan as Cynthia, and Alejandro Vera as Miss Understanding.

[34] Eight years after the first run in Auckland, the show returned to the Civic Theatre from 16 October to 13 November 2016, starring Bryan West as Tick/Mitzi, Simon Green as Bernadette, and André Torquato as Adam/Felicia.

[35] From 8 to 29 December 2016, Priscilla ran at the Nissay Theatre, Tokyo, with Ikusaburo Yamazaki as Tick/Mitzi, Takanori Jinnai as Bernadette, and Yunhak from Supernova and Keita Furuya alternating as Adam/Felicia.

[37] After closing in Paris, the production was expected to embark on a national tour, set to launch in January 2019, but it was cancelled due to poor ticket sales.

[40] From 14 December 2017 to 12 April 2018, a non-replica production ran at the Gärtnerplatztheater, Munich, with Armin Kahl as Tick/Mitzi, Erwin Windegger as Bernadette, and Terry Alfaro as Adam/Felicia, before transferring to the Theater St. Gallen, Switzerland, from 23 February to 31 May 2019.

[41][42] A tour to commemorate the 10th anniversary of the show began performances on 21 January 2018 at the Regent Theatre in Melbourne, with David Harris as Tick/Mitzi, Tony Sheldon reprising his role of Bernadette, and Euan Doidge as Adam/Felicia.

[46] On 5 September 2019 a non-replica UK tour launched at the Orchard Theatre, Dartford, starring Joe McFadden as Tick/Mitzi, Miles Western as Bernadette, Nick Hayes as Adam/Felicia, Daniel Fletcher as Bob, Claudia Kariuki, Rosie Glossop, and Aiesha Pease as The Divas, Miranda Wilford as Marion, Jacqui Sanchez as Cynthia, and Kevin Yates as Miss Understanding.

[49] From 25 August 2022 to 6 May 2023, a non-replica production ran at the Helsinki City Theatre, starring Lauri Mikkola as Tick/Mitzi, Clarissa Jäärni as Bernadette and Niki Rautén as Adam/Felicia.

[51] An immersive version of the show, Priscilla the Party!, also directed by Simon Phillips, opened on 25 March 2024 at HERE at Outernet in London, with Owain Williams as Tick/Mitzi, Dakota Starr as Bernadette and Reece Kerridge as Adam/Felicia.

[53] A non-replica production premiered on 2 August 2024 at the Centro Teatral Manolo Fábregas in Mexico City, starring Jesús Zavala as Tick/Mitzi, Alejandra Bogue and Roshell Terranova alternating as Bernadette, and José Peralta as Adam/Felicia.

[54] A second Spanish production officially opened on 3 October 2024 at the Teatre Tívoli, Barcelona, with Víctor González as Tick/Mitzi, Sharonne as Bernadette, Daniel Garod as Adam/Felicia, Esteban Oliver as Bob, Rossana Carraro, Anna Lagares and Paula Moncada as The Divas, Sara Navacerrada as Marion, Malia Conde as Shirley, Etheria Chan as Cynthia, and Raúl Maro as Miss Understanding.

The Star favorably wrote: "This eye-popping, ear-pleasing, toe-tapping honey of a show moves like a cyclone from start to finish and will leave you gasping for breath on numerous occasions, thanks to its spectacular spectacle, its raunchy humour and its virtuoso performances.