Pristiguana is an extinct genus of possible iguanian lizard from the Maastrichtian Marília Formation of Brazil.

Its discoverers said, in 1973, that it is originally considered as the oldest fossil lizard in the family Iguanidae.

However, in 2012 study, phylogenic analysis found that it was a primitive iguanian forming a clade with Huehuecuetzpalli (which is considered as stem-squamate in more recent studies[2][3][4]).

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