ProBiS is a computer software which allows prediction of binding sites and their corresponding ligands for a given protein structure.

The name ProBiS originates from the purpose of the software itself, that is to predict for a given Protein structure Binding Sites and their corresponding ligands.

The latter connects ProBiS and CHARMMing servers into one functional unit that enables prediction of protein−ligand complexes and allows for their geometry optimization and interaction energy calculation.

The ProBiS CHARMMing server with these additional functions can only be used at National Institutes of Health, USA.

They enable viewing of predicted binding sites and ligands poses in three-dimensional graphics.