Unlike the Athens Suburban Railway, the three lines served are rather medium-distance regional rail connections on three major axes to Edessa and Serres, Central Macedonia, and Larissa, Thessaly.

[2] Thessaloniki Suburban Railway consists of three lines: Trains run from approximately 6:00 am to 22:00 pm daily on a fairly irregular basis, roughly once an hour.

In the future, the construction of an intermediate stop in Panteleimon between Neoi Poroi and Leptokarya is foreseen for the re-service of Platamonas.

Then, it continues southwest along Lake Vegoritida to Amyntaio, and after turning north to Vevi, it heads west for the last time to reach Florina.

The line connected the urban centres of Thessaloniki, Veria, Florina, and Edessa as well as the waterfalls of the same name, thus uniting areas of Central and Western Macedonia.

Services commenced on 3 February 2020 on what is the 3rd line of the Thessaloniki suburban network, Forming the daily connection of the two cities with existing intermediate stations.

[8][9] In May 2008, the Greek government's National Transport Plan outlined the aspiration for a second link to Edessa, via Giannitsa serving Chalkidona and Pella along the way, of 50 km (31 mi) in length allowing a 30-minute reduction in journey time.