[3][4][1][5] The IUCN conservation status of Procambarus acutus is "LC", least concern, with no immediate threat to the species' survival.

It has a disjunct native distribution which includes the Atlantic Slope, as well as the southern Great Lakes drainages to the Gulf of Mexico.

[2][9] Procambarus acutus also occurs from southern Wisconsin and Michigan through Kentucky and Missouri to western Texas and the Florida panhandle.

[8][9][10] Procambarus acutus has spread beyond the American states it is native to and is now found in most of the Continental US.

[11] These crayfish are also found in Egypt,[11] Great Britain,[12] and the Netherlands[11][12] however there is insufficient information at this time to assess their degree of establishment or invasiveness.