When he was 12 years old, he followed his older brother, Neophytus, metropolitan bishop of Ganos and Chora (Eastern Thrace), who helped him finish basic education.
Later, he ordained him deacon and presbyter, and when Neophytus died in 1759, Procopius succeeded him, after request of the people of the metropolis.
During the period 1780–1782, Procopius was a member of the Synod of the Ecumenical Patriarchate and resided in Constantinople.
With decree from the Sultan, Selim III, he was forced to resign on 30 April 1789 and was exiled to the Great Lavra in Mount Athos.
Later, his bones were transported to the Monastery of Mardakios, after the cares of the metropolitan bishop of Messenia, Meletios Sakellaropoulos.