The cover artwork was created by Israeli artist Eliran Kantor based on the album's lyrical themes as explained to him by Chuck Sherwood.

In an interview with And Justice For Art, Kantor stated that Sherwood "showed me the lyrics he wrote and went into details about the themes behind each song.

I imagined the deity having an arachnoid body made of tar, with the locusts draping it with skin bits they pick from a pit full of human sacrifice.

José Carlos Santos of Terrorizer gave the album a high rating, and wrote, "Tenth full-length 'Profane Nexus' is vintage Incantation [...] it maintains that unbeatable dirty subterranean feeling of the band's early classics with an extra bit of bite soundwise [...] to show that the band isn't frozen in time either.

"[7] Sputnikmusic were more critical of the album, writing that "Everything is just too tidy and measured, right down to the typewriter drums and quintessentially Relapse guitar-tone."