For his former student Anneliese Deckert and her colleague Daniel Winter – who both work for the criminal investigation department in Cologne – Professor T. is their only hope to solve almost unsolvable crimes.

But Anneliese and Daniel are unperturbed and build an unbeatable team with Professor T. Chief Commissioner Paul Rabe disapproves and feels left out.

Christina Fehrmann, head of the criminal investigation department, considers T's collaboration with mixed feelings because she and T were once a couple.

The German newspaper Frankfurter Allgemeine Zeitung wrote about the first season of Professor T., that Jasper Thalheim (Matthias Matschke) and Anneliese Deckert (Lucie Heinze) have the potential to become identification figures with humour for the ZDF like the successful investigators of the Tatort in Münster are for the ARD.

[8] The German newspaper Neue Osnabrücker Zeitung praises the lead actor Matthias Matschke, because he succeeded in playing Professor T. as an arrogant dislikable guy with vulnerability and helplessness.