The street runs from Ho Chi Minh Square to the Moscow Ring Road.

[1][2] The street appeared in the early 1950s after the development of the 1st quarter of Novye Cheryomushki and originally did not have a name.

[4] In 2003, three squares dedicated to the Russian poets Pushkin, Lermontov and Tyutchev were created at the beginning of the street.

On Profsoyuznaya Street, at the junction of Novoyasenevsky Prospekt, there is the highest point in Moscow, the height of which is 255 metres (837 ft) above sea level.

[5] There are 7 stations of the Kaluzhsko-Rizhskaya Moscow Metro line on Profsoyuznaya Street: Akademicheskaya, Profsoyuznaya, Novye Cheryomushki, Kaluzhskaya, Belyayevo, Konkovo, Tyoply Stan, and 1 station of the Big Circle Line: Vorontsovskaya.