The Progress M-13M spacecraft lifted off from the Baikonur Cosmodrome in Kazakhstan at 10:11 UTC on 30 October 2011, starting off the 45th uncrewed Russian space station resupply mission.

Approximately nine minutes following the liftoff, the Progress M-13M spacecraft successfully reached orbit and deployed its solar arrays and navigation antennas.

After arriving to the vicinity of the ISS, Progress M-13M began a flyaround maneuver to get lined up with the docking port.

It then executed a roll maneuver to properly orient its forward nose probe with the Pirs Docking Compartment.

The Expedition 29 crew of Michael E. Fossum, Sergey Volkov and Satoshi Furukawa opened the hatches and entered the Progress spacecraft later on the day.

[12] The de-orbit braking maneuver for disposal into the South Pacific Ocean was initiated at 02:25 UTC on 25 January 2012 and lasted for three minutes and 56 seconds.

The demise of Progress M-13M in the ocean ended the 86-day, 17-hour voyage that it began with a launch atop a Soyuz booster from Baikonur Cosmodrome in Kazakhstan on 2 November 2011.