[1] Progress M-45 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome.

[1] The spacecraft docked with the aft port of the Zvezda module at 09:51:32 UTC on 23 August 2001.

[2][3] It remained docked for 91 days before undocking at 16:12:01 UTC on 22 November 2001[2] to make way for Progress M1-7.

Progress M-45 was deorbited at 20:48:00 UTC on the same day that it undocked.

[2][5] Progress M-45 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.