[1] Progress M1-6 was launched on the maiden flight of the Soyuz-FG carrier rocket, flying from Site 1/5 at the Baikonur Cosmodrome.

[1] The spacecraft docked with the aft port of the Zvezda module at 00:23:57 UTC on 23 May 2001.

[2][3] It remained docked for 91 days before undocking at 06:02 UTC on 22 August 2001[2] to make way for Progress M-45.

[4] It was deorbited at 09:00 UTC on the same day,[2] burning up in the atmosphere over the Pacific Ocean, with any remaining debris landing in the ocean at around 09:50 UTC.

[2][5] Progress M1-6 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.