Prohegetotherium is an extinct genus of hegetotheriid notoungulates from the Late Oligocene to Early Miocene (Deseadan-Santacrucian in the SALMA classification) of the Agua de la Piedra,[1] Mariño & Sarmiento Formations of Argentina, the Petaca and Salla Formations of Bolivia, and Fray Bentos Formation of Uruguay.

[2][3] Prohegetotherium comprises three species, P. sculptum, P. schiaffinoi, and P.

[2] Although Prohegetotherium shumwayi and P. crassus have long been synonymized with P. sculptum, Kramarz and Bond (2017) restricted P. sculptum to the holotype, rejecting the synonymy.

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