Pseudotypotherium is an extinct genus of notoungulates, belonging to the suborder Typotheria.

It was close to the size of a sheep, and Pseudotypotherium is considered as one of the largest known typotheres.

The genus Pseudotypotherium was first described in 1904 by Florentino Ameghino, based on fossil remains found in Argentina in Late Pliocene terrains.

Pseudotypotherium was a typical member of Typotheria, a clade of notoungulates which, during their evolution, independently developed several anatomical characteristics similar to those of rodents, probably occupying numerous ecological niches only occupied by rodents on the other continents.

Pseudotypotherium was a member of the family Mesotheriidae, which included some of the most specialized typotheres.