The first two seasons were filmed at Carson, California's Home Depot Center, which was referenced in aerial shots.

Each of the first nine episodes of Pros vs. Joes consisted of a team of five professional athletes, distinguished by their uniform color on the show.

Winner: Charlie Brenneman Each of the second-season episodes of Pros vs. Joes consisted of a team of four professional athletes, distinguished by their uniform color on the show.

Winner - Jay McKeown For Season Three, the format was changed to a "Last Man Standing" format, akin to the NCAA Division I men's basketball tournament with regionals held at the now demolished Miami Orange Bowl, Robert F. Kennedy Memorial Stadium in Washington, D.C., the Louisiana Superdome in New Orleans and the Rose Bowl in Pasadena, California, where the finals were also held.

Sudden death: Wrestling battle royal Joes: Eddie Dubose, Brent Allen, Jason Vogel, Matt Hill, Dallas Robinson, Steve Ruff Winner: Jason Vogel sudden death: Punt Return for TD Joe: "Iron" Mike Hall, Robert Foster, Mark Rohling, Donnie Frazier, Faheem Hammett, and Kevin Witt Winner: Donnie Frazier (Hall gave it to him) [1] Sudden Death: rebounding Joes: Jay Williams, Micheal Martin, Chris Rich, Tony Railing, Derek Schafer, Will Hunter Winner: Derek Schafer Sudden Death: onside kicks Joes: Mike Kotsch, Pablo Healing, Rahul Soni, Jermaine Reid, Joe Goodwin, John Grkovic Winner: Joe Goodwin Sudden Death: TD Returns Joes: Terrius Moseby, Dave Hubert, Dan Falkner, Jerry Lehman, Carvel Gardner, David Ortiz Jr Winner: David Ortiz Jr Sudden Death: scoop and score Joes: Clayton Monte, Greg Macaluso, Brian Peters, Mark Kilibarda, Art Miller, Devon Tilly Winner: Clayton Monte Sudden Death: intercept the ball Joes: Dion Santo, Clarence Chaney, Adam Wasserman, Justin Simonsen, Micheal Stange, Trent Madsen Winner: Trent Madsen Sudden Death: strip the dummy Joes: Red Simmons, Gabriel Canape, Cory Driggs, Cakvin Lafiton, Tim Fritz, Kirby Sykes Winner: Gabriel Canape For the fourth season, which premiered April 27, 2009 at 11 pm ET/PT, the new hosts are FOX Sports NFL Sunday regulars Michael Strahan and Jay Glazer, and is titled "Pros vs. Joes All Stars".