Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring.

It is an effective hypnotic drug showing efficacy in increasing the time spent asleep as well as reducing awakenings during the night.

[8] Estazolam also has anxiolytic properties and due to its long half life can be an effective short-term treatment for insomnia associated with anxiety.

Estazolam should only be used short term and at the lowest effective dose to avoid complications related to long-term use.

[18] Estazolam at high doses decreases histamine turnover via its action at the benzodiazepine-GABA receptor complex in mouse brains.

[24] An animal study in rabbits demonstrated that estazolam induces a drowsy pattern of spontaneous EEG including high voltage slow waves and spindle bursts increase in the cortex and amygdala, while the hippocampal theta rhythm is desynchronized.

The photic driving response elicited by a flash light in the visual cortex is significantly suppressed by estazolam.