Prospect road starts in the industrial suburb of Gepps Cross, at the intersection with Waldaree Street.

It crosses Fitzroy Terrace and ends soon after, meeting the southern end of Main North Road and O'Connell Street, on the northern edges of North Adelaide.

[4] There are many murals, sculpture pieces and significant buildings along the length of Prospect Road.

Recognisable pieces include Pulse by Warren Langley which are illuminated clusters of two and three stylised 'blossoms' of varying size in the Prospect Village Heart.

In 2017 Port Adelaide Enfield completed a 3-stage upgrade including paving, landscaping and artwork in Kilburn and Blair Athol.