Protase Rugambwa (born 31 May 1960) is a Tanzanian prelate of the Catholic Church who has been metropolitan archbishop of the Archdiocese of Tabora since November 2023, after serving as coadjutor there for seven months.

[3] He was ordained a priest for the Diocese of Rulenge on 2 September 1990 in Dar-es-Salaam by Pope John Paul II during his pastoral visit to Tanzania,[4] He was parish vicar of Mabira for 1990-91.

He taught at the Minor Seminary of Katoke from 1991 to 1994, with responsibility for the liturgy and serving also as chaplain of Biharamulo hospital.

On 26 June 2012, Pope Benedict appointed him adjunct secretary of the Congregation for the Evangelization of Peoples and president of the Pontifical Mission Societies, replacing Archbishop Piergiuseppe Vacchelli, who had reached retirement age.

[12] Protase Rugambwa: Ministry and collaboration in small Christian communities: ″Communities in Rulenge Diocese-Tanzania, a case study", dissertation, Pontificia Università Lateranense, Rome, 1998.