TRH synthesizing neurons of the paraventricular nucleus project to the medial portion of the external layer of the median eminence.

[4][5] Both parties insisted their labs determined the sequence first: Schally first suggested the possibility in 1966, but abandoned it after Guillemin proposed TRH was not actually a peptide.

Guillemin's chemist began concurring with these results in 1969, as NIH threatened to cut off funding for the project, leading both parties to return to work on synthesis.

[6] Schally and Guillemin shared the 1977 Nobel Prize in Medicine "for their discoveries concerning the peptide hormone production of the brain.

"[7] News accounts of their work often focused on their "fierce competition" and use of a very large amount of sheep and pig brains to locate the hormone.

[14] After intrathecal administration, shaking, sweating, shivering, restlessness, and mild rise in blood pressure were observed.