Between 1801 and 1803 she made two complete voyages from Liverpool as a slave ship in the triangular trade in enslaved people.

[2] On 6 January 1802 Prudence, Woodstock, master, sailed for Africa.

Prudence sailed from Kingston on 21 May and arrived back at Liverpool on 5 July.

[1] Captain James Swanson sailed from Liverpool on 5 September 1802.

[6][a] Captain Johnathan D'Arcy acquired a letter of marque on 30 July 1803.