Johann Sebastian Bach used verses from the psalm in his early cantata, Nach dir, Herr, verlanget mich, BWV 150.

Additionally, these acrostic Psalms serve a dual purpose, functioning as mnemonic tools and pedagogical instruments for conveying instruction.

[5] Psalm 25:8 affirms the inherent goodness and uprightness of the LORD, thereby elucidating His commitment to instructing those who transgress in the path of righteousness.

[clarification needed] As an acrostic, the verses in the psalm are arranged according to the Hebrew alphabet, with the exception of the letters Bet, Waw and Qoph which together, according to Jewish interpreters, made reference to the word gehinom (hell).

That is why, from the sixth century, the Church begins the first Sunday of Advent with the first verses sung of it, namely the Introit in Old Roman and Gregorian, pending the Nativity.

It is part of the fourth Kathisma division of the Psalter, read at Matins on Monday mornings, as well as on Wednesdays during Lent at the Sixth Hour.

[citation needed] Hymns derived from Psalm 25 include Heinrich Bone's "Zu dir, o Gott, erheben wir", published in 1851.

Heinrich Schütz composed a setting of metred German text, "Nach dir verlangt mich", SWV 122, as part of the Becker Psalter.

Johann Sebastian Bach composed an early cantata, Nach dir, Herr, verlanget mich, BWV 150, which alternates verses from Psalm 25 and poetry by an unknown librettist.