[4] Alexander Kirkpatrick also suggests that this psalm "ends the first book of the Psalter ... with a hope, destined to be illuminated with a new light by the revelation of the Gospel".

[7][8] Psalm 41 is quoted in the New Testament Judas Iscariot is seen as the man who "lifts his heel" against his friend with whom he shared bread.

In the Church of England's Book of Common Prayer, this psalm is appointed to be read on the evening of the eighth day of the month.

[13] Heinrich Schütz wrote a setting of a paraphrase of Psalm 41 in German, "Wohl mag der sein ein selig Mann", SWV 138, for the Becker Psalter, published first in 1628.

The English text of Handel's Foundling Hospital Anthem for choir, composed for a fundraising concert, is adapted from the beginning of the psalm.