A thoroughly Christological interpretation can be found in Martin Luther's work, who finds the third verse revealing that the humanization of man happens through the incarnation of Jesus Christ.

[20] In the Church of England's Book of Common Prayer, Psalm 5 is appointed to be read on the morning of the first day of the month.

[21] Caspar cross Hamer (1546) created in 1537 the chorale An geystlich Bitlied drawn heavily from the Psalms.

Heinrich Schütz composed a setting of a metred version in German, "Herr, hör, was ich will bitten dich", SWV 101, published in 1628 in the Becker Psalter.

Felix Mendelssohn composed a setting of Psalm 5 in English, "Lord, hear the voice" for men's chorus in 1839).

In 1911, Edward Elgar dedicated a setting for choir and orchestra, "Intende voci orationis meæ", as an offertory for the coronation of King George V.