Jerome's translation gave rise to mystical interpretations involving the Sacred Heart in early modern Christian tradition.

For example, Serafino Porrecta, in his Commentaria in Psalterium Davidicum, interprets this in terms of Christ himself being the Man who can "accede to that exalted heart", Hic [Christus] solus accessit ad illum cor altum.

[9][10] In the current Liturgy of the Hours, Psalm 64 is recited or sung at the midday office on the Saturday of the second week of a four-weekly cycle of liturgical prayers.

In the Church of England's Book of Common Prayer, this psalm is appointed to be read on the morning of the 12th day of the month.

[11] Heinrich Schütz set Psalm 64 in a metred version in German, "Erhör mein Stimm, Herr, wenn ich klag", SWV 161, as part of the Becker Psalter, first published in 1628.