Pseudonajatoxin b

Pseudonajatoxin b, or Pt-b, is a highly potent and lethal long-chain α-neurotoxin found in the venom of the eastern brown snake (Pseudonaja textilis).

Pseudonajatoxin b is present in the venom of the highly lethal eastern brown snake, Pseudonaja textilis,[1][2] which is the leading cause of snakebites in Australia.

Additionally, they are present in the central nervous system, where they play an important role in autonomic processes, including the regulation of heart rate and respiration.

[9] Furthermore, long-chain α-neurotoxins typically bind tightly and irreversibly to nicotinic receptors, resulting in permanent channel inactivation once they are bound.

[5] Although the specific lethal mechanisms of pseudonajatoxin b remain unknown, it is well established that both α-neurotoxins and the venom of P. textilis induce paralysis, leading to death through asphyxiation.

Amino acid sequence of pseudonajatoxin b. Disulfide bonds depicted in green. Retrieved from UniProt database. [ 4 ]
AlphaFold structure model of Pseudonajatoxin b. Colors indicate the model confidence, ranging from very high (dark blue) to very low (orange). Retrieved from UniProt database. [ 4 ]