The player has to use Lucia's psionic weapons strategically in levels using different elements to their advantage (in the ice stage, rocks being doused by falling water can be frozen and used as a stable platform for Lucía to jump on by blasting the rock with the ice shot, while the sonic wave weapon can destroy certain foreground objects blocking her path).

Taking place at a remote laboratory in the year 19XX, a three-staff research team consisting of Dr. Knavik and his assistants the TWIN sisters Cecile and Lucia is studying the exploration and usage of ESP.

Dr. Knavik explains that part of his experiments involved running tests on a variety of monsters, but eventually the subjects rebelled and took Cecile with them.

As Lucia follows the monster's track, Dr. Knavik gives her the ESP Booster, a device he created that will enable the user to wield psychic powers.

Psychic World for the Master System was given mixed but mostly positive reviews 70% by RAZE,[1] and 69% by Video Games.