Although never developed into an effective weapons system, psychochemical warfare theory and research—along with overlapping mind control drug research—was secretly pursued in the mid-20th century by the US military and Central Intelligence Agency (CIA) in the context of the Cold War.
The use of chemicals to induce altered states of mind dates back to antiquity and includes the use of plants such as thornapple (Datura stramonium) that contain combinations of anticholinergic alkaloids.
[3] Records indicate that in 1611, in the British Jamestown Colony of Virginia, an unidentified, but toxic and hallucinogenic, drug derived from local plants was deployed with some success against the white settlers by Chief Powhatan.
[4] In 1881, members of a French railway surveying expedition crossing Tuareg territory in North Africa ate dried dates that tribesmen had apparently deliberately contaminated with Egyptian henbane (Hyoscyamus muticus, or H. falezlez), to devastating effect.
In the same period, the US Army undertook the secret Edgewood Arsenal human experiments which grew out of the U.S. chemical warfare program and involved studies of several hundred volunteer test subjects.