In North America, Viz Media licensed the series for English release and serialized its chapters in Shonen Jump.

After Ageha Yoshina beats up a bully for 10,000 yen, he heads home anticipating a scolding from his sister for breaking curfew.

Shrugging it off, he places the receiver back only to find a mysterious calling card with the word "Psyren" written on it.

The same day, he finds his classmate's (Sakurako Amamiya's) wallet, which some other girls hid, and notices she has the same card.

In a panic, he picks up and is suddenly drawn into the world of Psyren, which is a wasteland inhabited by monsters called Taboo.

The voice from the phone, dubbed Nemesis Q, assigns missions which people must complete if they wish to return home.

Ageha and his companions meet a group of kids who are adopted by Elmore Tenju, the old lady who placed the 500 million prize offer, as the game progresses.

The game continues until eventually, Ageha, Sakurako, Hiryū Asaga, Oboro Mochizuki, and Kabuto Kirisaki are the only contenders left.

They are trained by former Psyren contestant Matsuri Yagumo and the psychic children from the Tenju Roots Orphanage.

No.7 contacts Ageha while he is in the coma, revealing the outcome of the Psyren timeline—Miroku and Grana sacrificed their lives to destroy Ouroboros and Mithra.