[1] In the United Kingdom it is categorised as 'Nationally Notable B' by the National Biodiversity Network and thus appears in between 31 and 100 hectads (10 km grid squares) across the country.

[1] The six-spotted spider beetle has been generally associated with pine forests,[5] although more cosmopolitan sightings have occurred indoors.

[6][7][8] The larvae of P. sexpunctatus are commensals in the nests of cavity-nesting solitary bees in the genera Osmia and Megachile.

[1] One example has been recorded, from Nova Scotia, Canada, in the nest of the Blue Orchid Mason Bee (Osmia lignaria).

The prevalence, or at least the recording, of P. sexpunctatus may be increasing due to the rise in the number of commercially available bee hotels used in domestic gardens.