According to surviving inscriptions at Telmessos, Ptolemy II didn't seem to have a royal title nor is his relationship with the Pharaohs in Alexandria clear.
[21] At an unknown date, during his father's reign, Lysimachus with his family were enjoying excellent, cordial relations with the Seleucid monarch Antiochus III the Great.
[29] According to an intact stone inscription found in Nahavand Iran dated in 193 BCE, Ptolemy II is described as a relative of Antiochus III.
The first letter is from Antiochus III addressed to the Strategos of the Carian Satrapy and is the above-mentioned stone inscription from Nahavand, Iran: The second letter is addressed to the Hyparch of the district from the Strategos of the Carian satrapy: Around the time Berenice was appointed as chief-priestess, Ptolemy II sold part of his land holdings in the Telmessos region to Antiochus III.
The reason for Antiochus III in purchasing part of Ptolemy II's land holdings were to settle Kardakian mercenaries near Telmessos.
[33] During the Treaty of Apamea in 188 BC, Antiochus III was forced to give the region of Lycia to the King Eumenes II of Pergamon.
[35] According to dedication inscriptions on the Greek island of Delos, Ptolemy II made offerings of thanks for the Peace of Apamea.