In 300 BC, at which time she could not have been more than seventeen years of age, her hand in marriage was sought by Seleucus, king of the Seleucid Empire.

Seleucus and Stratonice had one child, a daughter Phila, when it was discovered that her stepson Antiochus was deeply enamoured of her.

In order to save the life of his son (which was supposedly endangered by the violence of his passion), Seleucus gave up Stratonice in marriage to him in 294 BC.

[3][4] In Babylonian texts, she is referred to as 'Astartanikku', a transliteration of her Greek name that seems to have been designed in order to draw a parallel with the goddess Astarte.

[5] Stratonice's death at Sardis is mentioned in the Astronomical Diaries in September or October 254 BC.