Publio Maria Sant (26 August 1779 – 28 October 1864) was a Maltese prelate who became bishop of Malta in 1847.
His father, Giovanni Francesco, was the 2nd Count Sant while his mother, Chiara Bonici-Platamone-Xara-Cassia, was the 7th Baroness of Ghariexem and Tabia in her own right.
His grandfather, Baldassare Salvatore Sant, was created count by Maria Theresa, the Empress of Austria and Queen of Hungary and Bohemia, in her Italian territories.
Archbishop Sant is well known in Sliema as the one who gave permission for the construction of a new church dedicated to Our Lady of Stella Maris in 1852.
His brother, Count Luigi Maria Sant-Cassia, was married to the niece of Cardinal Fabrizio Sceberras-Testaferrata.