It borders the municipalities of Salgar and Tarso to the north, Jericó to the east, Andes to the south, and Ciudad Bolívar and Hispania to the west.

In 1540, a Spanish lieutenant from the conquering troop of Marshal Jorge Robledo was tasked with exploring the territories along the Cauca River, starting from the city of Arma towards the north.

This expedition explored a large area of what is now known as Southwest Antioquia, including the lands of present-day Pueblorrico.

In 1825, a group of settlers from the city of Medellín, led by Gabriel Echeverri, offered to purchase vast lands in this area from the government, successfully negotiating the transaction.

Pueblorrico boasts beautiful landscapes, several picturesque streams, and access to a natural reserve.