The species is among the most common lizards in Puerto Rico, and also native to Vieques, Culebra, and the Virgin Islands (except St. Croix).

The sharp-mouthed lizard measures approximately 35 to 43 mm (1.4 to 1.7 in) in length from snout to vent.

The species has a yellow-brown color with males having a purple dewlap that blends into crimson near the tip.

The anoles of the Greater Antilles have been extensively studied since they represent an interesting case of adaptive radiation.

[4] Anolis pulchellus is considered a grass-bush anole, occurring primarily in bushes or grass.