This highway consists of one lane in each direction for most of its length between Naranjito and Corozal.

[7] In Corozal, PR-164 travels from the Naranjito municipal limit to its western terminus at PR-159 junction, passing through Palmarejo and Barrio Pueblo.

[8] Among the most important intersections are PR-5, that goes to Bayamón; PR-152, that heads to Barranquitas; PR-159, the main highway between Morovis and Toa Alta; PR-165, which leads to Toa Alta, and PR-167, the main road between Comerío and Bayamón.

Puerto Rico Highway 164 crosses the following rivers: The entire length of PR-164 is part of the eastern section of the old Road No.

20, a highway that led from Naranjito to Ciales through Corozal and Morovis until the 1953 Puerto Rico highway renumbering, a process implemented by the Puerto Rico Department of Transportation and Public Works (Spanish: Departamento de Transportación y Obras Públicas) that increased the insular highway network to connect existing routes with different locations around Puerto Rico.