In addition, American oil magnate Harry Ford Sinclair sponsored the team with generous donations until 1935.

In the early years, Pumas had a long string of consecutive championships from 1933 to 1945 (including an appearance in the 1945 Sun Bowl; this was followed by the so-called "Golden Age" of 1946 to 1957.

Unfortunately, conditions within the league and the existence of other powerful newcomer squads undermined the strength and dominance of the team.

The team has an historic rivalry with Aguilas Blancas IPN, due to both of them being the biggest public universities in the country.

The team plays at the Estadio Olímpico Universitario in Mexico City, inaugurated in 1952 with the game between Pumas and Burros Blancos.