The pomegranate ellagitannins, which include punicalagin isomers, are ellagitannins found in the sarcotestas, rind (peel), bark or heartwood of the pomegranate fruit (Punica granatum).
As the chemistry of punicalagins became known it was found to be not unique to pomegranate.
("Fructus Chebulae"), myriocarpa, catappa and citrina (tropical flowering trees historically used in African traditional medicine for antibiotic and antifungal purposes).
[3] Pomegranate fruits natural phenols can be extracted with ethyl acetate and fractionation can afford the ellagitannin punicalagins.
Extracts of pomegranate are also 'Generally Recognized As Safe' (GRAS) by the United States.