The purD RNA motif is a conserved RNA structure found in Campylobacterota, such as the genera Helicobacter and Campylobacter.

[1] The RNA is consistently found in the apparent 5' UTR of purD genes.

purD genes encode the enzyme Phosphoribosylamine-glycine ligase, which catalyzes an early step in de novo purine synthesis.

Although a possible cis-regulatory role was proposed for this motif, experimental results indicate that it overlaps the 6S RNA of the relevant species,[2] and that the second hairpin of the motif might not be biological.

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